Situated on a low rise and surrounded by tree shaded lawns, #110 Main Street is a solid, well-crafted Italianate house which possesses a rectangular, sidehall plan. Projecting from its north wall is a two story octagonal bay—both side bay and 3-bay main facades culminate in gables with return eaves. The front door is surmounted by a heavy door hood which is supported by long, diagonal wooden braces. Adjacent to the entrance is a polygonal bay with narrow windows. In general windows are cornice headed and contain 2/2 wood sash. Projecting from the roof are narrow, corbelled brick chimneys. This house's form and elements are similar to those of #120 Main Street, next door to the north.